{"id":454,"date":"2021-10-26T14:34:03","date_gmt":"2021-10-26T14:34:03","guid":{"rendered":"http:\/\/infinity.kreativgenes.in\/?page_id=454"},"modified":"2021-10-27T14:42:31","modified_gmt":"2021-10-27T14:42:31","slug":"prostate-cancer","status":"publish","type":"page","link":"http:\/\/infinity.kreativgenes.in\/index.php\/prostate-cancer\/","title":{"rendered":"Prostate Cancer"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"454\" class=\"elementor elementor-454\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5f054aac elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"5f054aac\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-321f0156\" data-id=\"321f0156\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-33aba8f9 elementor-widget elementor-widget-template\" data-id=\"33aba8f9\" data-element_type=\"widget\" data-widget_type=\"template.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-template\">\n\t\t\t\t\t<div data-elementor-type=\"header\" data-elementor-id=\"326\" class=\"elementor elementor-326\" data-elementor-settings=\"[]\">\n\t\t<div class=\"elementor-inner\">\n\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f9b975e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f9b975e\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-7203221\" data-id=\"7203221\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5d61b1a elementor-mobile-align-center elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"5d61b1a\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t<a href=\"tel:+918092121212\">\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-phone-alt\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">+91 8092121212<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-6e860e8 elementor-hidden-tablet elementor-hidden-phone\" data-id=\"6e860e8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fda0ff9 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"fda0ff9\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-map-marker\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Next to T. 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class=\"svg-icon\" width=\"18\" height=\"18\" aria-hidden=\"true\" role=\"img\" focusable=\"false\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M6 11h12v2H6z\" fill=\"currentColor\"\/><\/svg><\/span><span class=\"screen-reader-text\">Open menu<\/span><\/button>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-357\"><a href=\"http:\/\/infinity.kreativgenes.in\/index.php\/spect-gamma-scan\/\" class=\"elementor-sub-item\">SPECT (Gamma scan)<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-358\"><a href=\"http:\/\/infinity.kreativgenes.in\/index.php\/pet-c-t\/\" class=\"elementor-sub-item\">PET- C T<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-359\"><a href=\"http:\/\/infinity.kreativgenes.in\/index.php\/services\/\" class=\"elementor-sub-item\">Radionuclide Therapies<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-537\"><a href=\"http:\/\/infinity.kreativgenes.in\/index.php\/trodat\/\" class=\"elementor-sub-item\">Trodat<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-538\"><a href=\"http:\/\/infinity.kreativgenes.in\/index.php\/targeted-imaging-and-therapy\/\" class=\"elementor-sub-item\">TARGETED IMAGING AND THERAPY<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-539\"><a href=\"http:\/\/infinity.kreativgenes.in\/index.php\/nuclear-renal-scans\/\" class=\"elementor-sub-item\">NUCLEAR RENAL SCANS<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-541\"><a href=\"http:\/\/infinity.kreativgenes.in\/index.php\/nuclear-medicine-in-neuroimaging\/\" class=\"elementor-sub-item\">NUCLEAR MEDICINE IN 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role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Book Your Test<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1bdc570d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1bdc570d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4742aa7f\" data-id=\"4742aa7f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-44d9243a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"44d9243a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-49e75fed\" data-id=\"49e75fed\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75250c4 elementor-widget elementor-widget-text-editor\" data-id=\"75250c4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><p>With a new imaging agent in PET\/CT test, prostate cancer cells can be detected more precisely compared to all other known techniques.<br \/>The fact that the currently available imaging techniques remain inadequate in prostate cancers complicates the estimation of the metastasis of the disease; and consequently, makes it di\ufb03cult to provide a successful treatment. Standard imaging methods such as computed tomography, magnetic resonance imaging, and bone scan remain inadequate to show prostate cancer metastases.<\/p><p>Even standard FDG PET\/CT, considered as the best imaging technique today in the \ufb01eld of cancer, is not ideal in the evaluation of prostate cancer.<\/p><p>PSMA-PET is a targeted molecular imaging technique that utilizes a protein called Prostate-Speci\ufb01c Membrane Antigen (PSMA) on prostate cancer cells, and to detect and monitor that protein. The antibody binds to the PSMA, while Gallium-68 bound to the antibody allows for imaging the prostate cancer cells through the PET scanner. In this way, prostate cancer cells that has spread to the body can be much better detected.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12e9a9d1 elementor-widget elementor-widget-heading\" data-id=\"12e9a9d1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Why Choose 68 Ga PSMA for Prostate Cancer Staging ?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1661fc06 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1661fc06\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-66d4887c\" data-id=\"66d4887c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-349a057d elementor-widget elementor-widget-text-editor\" data-id=\"349a057d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><p><strong>Tumor specific<\/strong><br \/>Prostate specific membrane an<\/p><p>gen is a cell surface protein over-expressed in prostate cancer cells compared to benign prostac<\/p><p>ssue. 68Ga-PSMA detects presence of prostate cancer cells directly, rather than indirect<\/p><p>indicators of disease such as increased bone turnover (bone scan) or enlarged lymph node.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5fae8c8 elementor-widget elementor-widget-text-editor\" data-id=\"5fae8c8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><p><strong>One-stop shop imaging<\/strong><br>PSMA PET-CT can be used to image and characterize the primary tumor itself, lymph nodes (independent of&nbsp;size), distal visceral metastases and the bone metastases, all in 1 single scan.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17d2e71 elementor-widget elementor-widget-text-editor\" data-id=\"17d2e71\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><p>Tumor speci\ufb01c<\/p><p>Prostate speci\ufb01c membrane antigen is a cell surface protein over-expressed in prostate cancer cells compared to benign prostatic tissue. 68Ga-PSMA detects presence of prostate cancer cells directly, rather than indirect indicators of disease such as increased bone turnover (bone scan) or enlarged lymph node.<\/p><p><strong>One-stop shop imaging<\/strong><\/p><p>PSMA PET-CT can be used to image and characterize the primary tumor itself, lymph nodes (independent of size), distal visceral metastases and the bone metastases, all in 1 single scan.<\/p><p><strong>High sensitivity and speci\ufb01city<\/strong><\/p><p>Superior tumour to background contrast compared to other molecular tracers allows for detection of disease in small regional nodes and distant disease in bones or visceral organs.<\/p><p>Early detection of site of recurrence in patients with low level PSA rise who have had de\ufb01nitive therapy Concurrent diagnostic contrast enhanced CT scan of the chest, abdomen and pelvis allows anatomical correlation to foci of abnormal PSMA uptake, signi\ufb01cantly increasing sensitivity and speci\ufb01city of the examination.<\/p><p><strong>Comparable cost<\/strong><\/p><p>Similar cost to patients when compared with combined 18F-NaF or 99M-TC MDP bone scan and diagnostic CT of the chest, abdomen and pelvis together.<\/p><p><strong>Potential therapy in CRPC<\/strong><br \/>Lutetium-177-labeled anti-prostate-speci\ufb01c membrane antigen monoclonal antibody for metastatic, castration resistant prostate cancer, is also available for suitable patients.<\/p><p><strong>Clinical USES of 68Ga-PSMA PET\/CT<\/strong><br \/>&#8211; Primary staging in intermediate or high-risk disease according to D&#8217;Amico classi\ufb01cation<br \/>&#8211; Biochemical recurrence with low PSA-values (as low as 0.2 ng\/ml)<br \/>&#8211; Biopsy targeting aGer previous negative biopsy, but high suspicion of prostate cancer<br \/>&#8211; Monitoring of systemic treatment in metastatic castrate-resistant prostate cancer<br \/>&#8211; Active surveillance<br \/>&#8211; Treatment monitoring in metastatic castration- resistant prostate cancer undergoing radioligand therapy targeting PSMA(e.g. 177Lu-PSMA-ligand)<\/p><p><strong>PET-MRI imaging for prOState cancer<\/strong><br \/>It is now possible to combine the strengths of both modalities into one single study by doing a Prostate PET-CT with co-registered MRI.<\/p><p>While MRI would give superior resolution in characterising the tumor, the PET imaging would be the most sensitive for metastatic survey including the nodal, visceral and osseous disease.<\/p><p><strong>RADIOLIGAND THERAPIES IN METASTATIC PROSTATE CANCERS (INCLUDING LUTETIUM-PSMA THERAPY AND ALPHA THERAPIES WITH ACTINIUM):<\/strong><br \/>Currently administered in cases with metastatic castrate-resistant prostate cancer, it has demonstrated a signi\ufb01cant response. Even in progressive disease at onset, resistant to all conventional therapies, there is a documented response in 60% patients with an achievable median progression-free survival of 11-16 months<\/p><p>OTHER NUCLEAR MEDICINE PROCEDURES OR UROLOGY:<br \/>\u00b7 FDG PET-CT for non-prostatic urologic malignancies<br \/>\u00b7 Renogram (Tc-DTPA \/ Tc-MAG3) for evaluation of di\ufb00erential and absolute renal function and drainage<br \/>\u00b7 Renal cortical scintigraphy (Tc-DMSA) for evaluation of renal cortical infection<br \/>\u00b7 Direct \/ indirect VU re\ufb02ux studies<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3df9b68e elementor-section-boxed 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